Abstract
Obesity and type 2 diabetes (T2D) increase the prevalence and worsen the prognosis of more than a dozen tumor types; however, the mechanism for this association remains hotly debated. Here we discuss a potential role for insulin as the key hormonal mediator of tumor metabolism and growth in obesity-associated insulin resistance.
Keywords:
diabetes; insulin resistance; metabolism; obesity.
Copyright © 2019 Elsevier Inc. All rights reserved.
MeSH terms
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Cell Proliferation
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Diabetes Mellitus, Type 2 / epidemiology*
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Diabetes Mellitus, Type 2 / etiology
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Diabetes Mellitus, Type 2 / metabolism
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Disease Progression
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Humans
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Insulin / metabolism*
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Insulin Resistance
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Insulin-Like Growth Factor I / metabolism
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Neoplasms / epidemiology*
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Neoplasms / metabolism
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Neoplasms / pathology
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Obesity / complications
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Obesity / epidemiology*
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Obesity / metabolism
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Prevalence
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Prognosis
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Risk Factors
Substances
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IGF1 protein, human
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Insulin
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Insulin-Like Growth Factor I